Книга: Strychnine: Alkaloid, Chloride, Ligand, Glycine Receptor, Robert Burns Woodward, Wieland-Gumlich Aldehyde, The Mysterious Affair at Styles, Strychnine Poisoning, Avicide

High Quality Content by WIKIPEDIA articles! Strychnine is a very toxic (LD50 = c. 10 mg/kg), colorless crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine causes muscular convulsions and eventually death through asphyxia or sheer exhaustion. The most common source is from the seeds of the Strychnos nux vomica tree. Strychnine is one of the most bitter substances known. Its taste is detectable in concentrations as low as 1 ppm. Strychnine acts as a blocker or antagonist at the inhibitory or strychnine-sensitive glycine receptor (GlyR), a ligand-gated chloride channel in the spinal cord and the brain.